If by "vacuum", you mean an absence of air molecules, well, since airborne sound is a vibration of air molecules, then no sound can traverse a vacuum.
If you stuck a speaker in a thermos (a vacuum bottle) you would hear it because the vibrations would be transferred mechanically and vibrate the whole bottle (there is a connection between the inner and outer bottles at the top of the thermos.) This is called 'structure-borne' sound.
To try to reduce sound in a room with some kind of vacuum would be folly. You'd have to turn the whole room into a vacuum chamber (so much for breathing...). A container pulling a vacuum placed in the middle of the room would create a nice dead spot and would absorb some sound, but overall it wouldn't be practical.
